Edgar Seipenbusch was born at Velbert in Germany in 1936. He started playing the violin at the age of six and took up the piano four years later. He studied violin, piano, composition and chamber music at the Cologne High School for Music and became the first violinist of the Cologne University String Sextet which made a number of concert tours in Europe. He became second concert master of the Rhenish Chamber Orchestra in 1958, becoming its leader two years later.
Since 1962, Seipenbusch has worked with all the great Viennese Orchestras in a wide range of activities. He was in charge of opera and operetta at St. Poelten and has made a large number of recordings with the Vienna Chamber Orchestra. Between 1967 and 1972 he directed opera in Graz as well as guest conducting frequently in both Kiel and Frankfurt. Edgar Seipenbusch has also been guest conductor of the Vienna Chamber Orchestra on many occasions. In 1972 he became director of the opera at Innsbruck and has since worked on many TV productions with ORF and in Germany.